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Questions to ask a dermatologic surgeon about aging skin treatment Aging Skin Questionaire Which aging skin treatment is the correct one for me? What is the estimated cost of the procedure? How long is one appointment? How often do I need to receive treatment for my condition?

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How far apart are the treatments? How long is the recovery time associated with my procedure? Do you have before-and-after patient images to help to prepare me for what to expect? Will someone walk me through the process before going in for the treatment? What are the common side effects or complications associated with the procedure?

Will the treatment hurt? What are my pain management and anesthesia options? What should I expect after the procedure is performed i. General questions to ask before aging skin treatment Is a doctor on site? Is the doctor board-certified in dermatology or in another specialty with equivalent training and experience? Was my medical history taken? Federal Government. Read our disclaimer for details.

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Results First Posted : March 5, Last Update Posted : March 5, Study Description. This research study will test how well a light therapy mask works for women with mild to moderate hyperpigmentation brown spots and moderate to severe facial wrinkles, as compared to a "sham" or inactive investigational light therapy mask. The study will also test if the light therapy mask causes any irritation. For the first 12 weeks of the study, participants will use the assigned mask, along with a provided cleanser and sunscreen.

For the second 12 weeks of the study, participants will use just the cleanser and sunscreen. FDA Resources. Arms and Interventions. A facial cleanser will be used twice daily morning and evening. Outcome Measures. Eligibility Criteria. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision.

Inclusion Criteria: Has mild to moderate brown spots Has moderate to severe facial wrinkling Able to read, write, speak, and understand English In general good health If capable of having a child: must agree to practice a medically acceptable form of birth control. Intends to complete the study and willing to follow all study directions.

Evaluation of the Older Adult

Is taking medication that may cause skin sensitivity to light Has been using a product or medication that the study investigator determines will increase health risk to the subject or confuse the study results Has a facial skin condition e. Has skin cancer or a history of skin cancer. Has an immune deficiency disorder, active hepatitis, or an autoimmune disease. Has an uncontrolled metabolic condition e.

Plans to start or change a hormone replacement therapy during the study. Has participated in another study in the past 30 days or plans to during the study. Is an employee or relative of the Study Site, Investigator, or Sponsor. Contacts and Locations.

Evaluation of the Older Adult

Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials. More Information. These rheological properties confirm the high deformability and low gel stiffness and viscosity, allowing rapid tissue integration and the possibility to use it at different dermis levels up to the most superficial one. This was an open, single-center, pilot study conducted on 18 female volunteers under the control of dermatologists.

All the volunteers signed a consent form containing the information relative to the nature and procedures of the study. The main exclusion criteria were pregnancy, lactation, smoking, alcohol or drug abuse, having received skin treatments for esthetic correction in 6 months prior to the study start date, having already performed permanent dermal fillers in the past, dermatological diseases including dermatitis, cutaneous diseases in the tested area, recurrent facial and labial herpes as well as general diseases such as diabetes, endocrine disease, hepatic, renal, cardiac and pulmonary disorders, cancer, neurological diseases, drug allergy and inflammatory or immunosuppressive diseases.

The injections were given, according to the product leaflet, using two different techniques:. These techniques reduce and prevent the appearance of wrinkles and fine lines and preserve and restore the quality of the skin maintaining its elasticity, improving the thickness, firmness and hydration. Evaluation of the efficacy of the treatment was clinical qualitative and based on instrumental measurements quantitative , and was performed at each study visit. The clinical evaluation of the surface microrelief was based on the Beagley Gibson reference scale, which again spans from 1 to 4 Table 1.

Table 1 Glogau and Beagley Gibson scores used for clinical evaluation of the efficacy. A photographic record both static and dynamic of the face was taken using standardized procedures to allow comparable evaluation of the images.

Wrinkles - Diagnosis and treatment - Mayo Clinic

As for the instrumental evaluations, these were taken monolaterally on the cheek at all five visits of the study. The different measures were performed under standard environmental conditions, and the volunteers were acclimatized for 10—15 minutes before each measurement. The instrumental procedures included: optical colorimetry, using a tri-stimulus colorimeter Chroma Meter CR equipped with three special filters, which determines skin brightness; wrinkle pictures and profilometry using a Primos compact portable device GFMesstechnik, Teltow, Germany which measures and elaborates, thanks to a dedicated software, skin wrinkles and major skin profilometric parameters both in vivo and in skin replicas.

A self-grading evaluation was performed by each participant after both injections, using a visual analogic scale VAS; 10 units in length. The scale recorded all the major unpleasant sensations related to the injections, such as stinging, itching, tightening, burning, pain and discomfort. The investigators checked for any immediate local reaction tardive swelling, pain, erythema, bruising as well as any additional adverse event, including the systemic ones.

Of the 18 volunteers enrolled, 14 completed the entire study, while 4 participants prematurely stopped the trial for personal reasons not related with the study.

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No additional events potentially interfering with the results occurred during the study period. Forty-eight hours after the first injection T1i , a statistically significant improvement of the wrinkles grade around the eyes This improvement increased at the subsequent evaluation points In Figure 2B , representative facial images showing the area around the eyes at baseline T0 and 5 months after the first injection T5 are shown.

As it can be seen, there is a clear improvement in the wrinkles present at baseline. Notes: A Clinical evaluation of wrinkle grade around the eyes at the different time points. B Representative images of the area around the eyes before and after treatment. Figure 3 Clinical evaluation of vertical lip lines at the different time points.

Data on skin profilometry indicate an important and clinically relevant anti-wrinkle activity in the area around the eyes. Figure 6 Skin profilometry of the area around the eyes reporting A average roughness Ra, B total height Rt and C maximum depth Rv at the different time points.

Evaluation of anti‐wrinkle effects of a novel cosmetic containing niacinamide

Table 2 Percentage of subjects reporting a VAS score greater than 5. HA represents the most widely used dermal filler for the treatment of skin aging. All these characteristics have prompted the generation of several HA preparations. One of the most important characteristics of a dermal filler is its ability not only to ameliorate the skin aging process but also to maintain its efficacy for sufficient time.

To test the efficacy, duration and tolerability of the HA study product, clinical and instrumental evaluations, together with a subject self-evaluation, have been used.

Interestingly, for all the parameters evaluated, both clinical and instrumental evaluations were concordant in defining the clinical efficacy of the product in the treatment of facial wrinkles. Notably, the study was planned to determine the immediate effects and those lasting 5 months after the initial administration, and the results not only indicated a rapid amelioration of the parameters but also showed that these effects were even increased after the second injection and maintained for the entire period of the study.

This is a particularly relevant finding, which suggests that the use of a limited number of procedures can be sufficient to exert a clinically and statistically significant effect. Since the intradermal injection is not free from unpleasant effects, the possibility of producing a long-lasting effect with limited injections is certainly a plus for any HA-containing filler. The self-evaluation of the volunteers confirmed the tolerability of the product, which showed only a few unpleasant effects.

The results of this single-center study demonstrated the clinical efficacy in all the efficacy tests performed and good tolerability of the HA-based study product Viscoderm Hydrobooster. A particular advantage is the ability of the product to maintain its efficacy for a long time, thus helping to reduce the number of intradermal injections. The authors are grateful to Giovanna Damia for the help in writing the manuscript.

The authors report no other conflicts of interest in this work.